I'll always have a great deal of affection for Harpoon. I went to the first Harpoon Oktoberfest, back around 1990. Me and my friends were 3rd, 4th, 5th and 6th in line, IIRC, and hundreds of people showed up. These days thousands show for their multiple festivals.
On that day, the only other brewery in Boston was the gone and lamented Commonwealth Brewing Company brewpub, where Todd Mott (creator of the American Mild and Catherine the Great, as well as Harpoon's IPA) once brewed, with the Cambridge Brewing Company brewpub across the river. Sam Adams was around, but wouldn't have a brewery in Boston for 8 more years. So, Harpoon was the first production brewery in Boston since Haffenreffer closed in 1964, and Harpoon possesses Massachusetts Brewing Permit #001.